Asymmetric synthesis of alpha-amino acids via diastereoselective addition of (R)-pantolactone to their ketenes

被引：22

作者：

Calmes, M ^{[1
]}

Daunis, J ^{[1
]}

Mai, N ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,LAB AMINOACIDES PEPTIDES & PROT,UPRESA 5075,F-34095 MONTPELLIER 5,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(97)00143-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The diastereoselective addition of (R)-pantolactone to various amino ketenes derived from phthalylamino acids is reported. The configuration of the newly-generated asymmetric center is dependent on alkyl or aryl C alpha substitution. This method constitutes a novel and convenient way of amino acid deracemization. (C) 1997 Elsevier Science Ltd.

引用

页码：1641 / 1648

页数：8

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