Antimalarial activity of herbal extracts used in traditional medicine in Korea

被引：18

作者：

Park, H

Kim, MS

Jeon, BH

Kim, TK

Kim, YM

Ahnn, J

Kwon, DY

Takaya, Y

Wataya, Y

Kim, HS ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

[2] Wonkwang Univ, Coll Med, Dept Parasitol, Iksan 570749, South Korea

[3] Wonkwang Univ, Coll Oriental Med, Dept Pathol, Iksan 570749, South Korea

[4] Kwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

[5] Korea Inst Sci & Technol, Div Life Sci, Seoul 130650, South Korea

[6] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 11期

关键词：

Plasmodium falciparum; traditional Korean medicine; antimalarial drug; drug-resistant malaria; Coptis japonica; Kalopanax pictus;

D O I：

10.1248/bpb.26.1623

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aqueous extracts of 6 traditional Korean medicines used to treat malaria were tested in vitro for their antimalarial activity against Plasm odium falciparum. The EC50 values for the herbal extracts were in the range 1.4-8.1 mug/ml. Significant antimalarial activity was observed with Coptis japonica (EC50 = 1.4 mug/ml), but it demonstrated no selective toxicity (selectivity = 1). In contrast, Kalopyanax pictus showed antimalarial activity (EC50 = 4.6 mug/ml) and higher selective toxicity (>4). This indicated that K. pictus may be potent for a new antimalarial agent.

引用

页码：1623 / 1624

页数：2

共 8 条

[1] A trial for a DNA diagnosis of Plasmodium vivax malaria recently reemerging in the Republic of Korea using microtiter plate hybridization assay [J].