In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine

被引：81

作者：

Le Tran, Q

Tezuka, Y

Ueda, JY

Nguyen, NT

Maruyama, Y

Begum, K

Kim, HS

Wataya, Y

Tran, QK

Kadota, S

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

[2] WHO, Dept Essential Drugs & Med Policy, CH-1211 Geneva 27, Switzerland

[3] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

[4] Natl Univ Ho Chi Minh City, Ho Chi Minh City, Vietnam

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 86卷 / 2-3期

关键词：

Vietnamese medicinal plants; antimalaria; antiplasmodial; Plasmodium falciparum; FCR-3;

D O I：

10.1016/S0378-8741(03)00045-X

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC50 values less than 10 mug/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC50 value of 0.5 mug/ml. Activity-guided fractionation led to identification of berberine as the major active constituent. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：249 / 252

页数：4

共 18 条

[1] IN-VITRO ANTIMALARIAL ACTIVITY OF QUASSINOIDS FROM EURYCOMA-LONGIFOLIA AGAINST MALAYSIAN CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM ISOLATES [J].