Fibrinogen: Structure, function, and surface interactions

被引：124

作者：

Fuss, C ^{[1
]}

Palmaz, JC ^{[1
]}

Sprague, EA ^{[1
]}

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78229 USA

来源：

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY | 2001年 / 12卷 / 06期

关键词：

anticoagulant; fibrinogen;

D O I：

10.1016/S1051-0443(07)61437-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α116,β3 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.

引用

页码：677 / 682

页数：6

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