Interaction of cells with L-lactide/glycolide copolymers synthesized with the use of tin or zirconium compounds

Comparative studies have been carried out on the viability of cells culture and production of collagen on lactide/glycolicle copolymers synthesized using zirconium or tin initiators. Cell response of various cell types: fibroblast-like cells, osteoblast-like cells, monocyte/macrophagelike cells has been examined. Cell response depends on the kind of cells and the initiator used during the synthesis of the polymer. In a number of cases the cells grown on materials containing zirconium have been reported to have better survival (for example, Saos2 cells). An enhanced collagen production on these copolymers has been also observed. (c) 2005 Wiley Periodicals, Inc.