IL-18:: a key player in neuroinflammation and neurodegeneration?

被引：188

作者：

Felderhoff-Mueser, U

Schmidt, OI

Oberholzer, A

Bührer, C

Stahel, PF

机构：

[1] Charite Univ Berlin, Sch Med, Dept Trauma & Reconstruct Surg, D-12200 Berlin, Germany

[2] Charite Univ Berlin, Sch Med, Dept Neonatol, D-13353 Berlin, Germany

[3] Univ Basel, Childrens Hosp, CH-4005 Basel, Switzerland

来源：

TRENDS IN NEUROSCIENCES | 2005年 / 28卷 / 09期

关键词：

D O I：

10.1016/j.tins.2005.06.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin (IL)-18 is a potent inflammatory cytokine of the IL-1 family. It is synthesized as an inactive precursor (pro-IL-18), which is cleaved into its functionally active form by caspase-1. Resident cells of the CNS express IL-18 and caspase-1 constitutively, thus providing a local IL-18-dependent immune response. Recent studies have highlighted a crucial role for IL-18 in mediating neuroinflammation and neurodegeneration in the CNS under pathological conditions, such as bacterial and viral infection, autoimmune demyelinating disease, and hypoxic-ischemic, hyperoxic and traumatic brain injuries. This review provides a synopsis of the current knowledge of IL-18-dependent mechanisms of action during acute neurodegeneration in immature and adult brains.

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页码：487 / 493

页数：7

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