The impact of 6-month training preparation for an Ironman triathlon on the proportions of naive, memory and senescent T cells in resting blood

被引:21
作者
Cosgrove, Cormac [1 ]
Galloway, Stuart D. R. [2 ]
Neal, Craig [2 ]
Hunter, Angus M. [2 ]
McFarlin, Brian K. [3 ]
Spielmann, Guilllaume [1 ,3 ]
Simpson, Richard J. [1 ,3 ]
机构
[1] Edinburgh Napier Univ, Biomed & Sports Sci Res Grp, Edinburgh EH10 5DT, Midlothian, Scotland
[2] Univ Stirling, Hlth & Exercise Sci Res Grp, Sch Sport, Stirling FK9 4LA, Scotland
[3] Univ Houston, Dept Hlth & Human Performance, Lab Integrated Physiol, Houston, TX 77204 USA
关键词
KLRG1; Exercise immunology; Endurance training; Flow cytometry; RESPIRATORY-TRACT INFECTION; OXIDATIVE STRESS; RECEPTOR KLRG1; LIFE-STYLE; LYMPHOCYTES; EXPRESSION; SUBSETS; INTENSITY; EFFECTOR; CYTOMEGALOVIRUS;
D O I
10.1007/s00421-011-2273-9
中图分类号
Q4 [生理学];
学科分类号
071003 [生理学];
摘要
Athletes appear to be at a greater risk of illness while undertaking arduous training regimens in preparation for endurance events. As infection susceptibility has been linked with increased proportions of differentiated and senescent T cells in the periphery, changes in the proportions of these cell types due to long-term high-volume exercise training could have important implications for athlete infection risk. This study examined the effects of 6-month training preparation for an Ironman triathlon on the proportions of na < ve, memory and senescent T cells in resting blood. Ten club-level triathletes (9 males; 1 female: 43 +/- A 3 years) were sampled at 27 (December), 21 (January), 15 (March), 9 (May) and 3 (June) weeks before an Ironman Triathlon. An additional sample was collected 2-week post-competition (August). Four-colour flow cytometry was used for the phenotypic analysis of CD4+ and CD8+ blood T cells. Proportions of differentiated (KLRG1+/CD57-) CD8+ T cells and "transitional" (CD45RA+/CD45RO+) CD4+ and CD8+ T cells increased with training, as the values in June were elevated 37, 142 and 116%, respectively, from those observed in December. Proportions of senescent (KLRG1+/CD57+) CD4+ or CD8+ T cells did not change during the training phase. Two weeks post-race, proportions of differentiated CD8+ T cells had returned to baseline values, while the proportions of senescent CD4+ T cells increased 192% alongside a 31% reduction in na < ve (CD45RA+/CD45RO-) cells. In conclusion, increases in differentiated and "transitional" T cells due to arduous exercise training could compromise host protection to novel pathogens and increase athlete infection risk, although whether or not the composition of na < ve and differentiated T cells in blood can serve as prognostic biomarkers in athletes remains to be established.
引用
收藏
页码:2989 / 2998
页数:10
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