Emerging role for ERM proteins in cell adhesion and migration

被引：198

作者：

Arpin, Monique ^{[1
]}

Chirivino, Dafne ^{[1
]}

Naba, Alexandra ^{[1
]}

Zwaenepoel, Ingrid ^{[1
]}

机构：

[1] Inst Curie, CNRS, UMR 144, F-75231 Paris, France

来源：

CELL ADHESION & MIGRATION | 2011年 / 5卷 / 02期

关键词：

epithelial cells; membrane-cytoskeleton interface; morphogenesis; ERM proteins; cell adhesion; EPIDERMAL-GROWTH-FACTOR; ACTIN-BINDING-SITE; FERM DOMAIN; EZRIN/RADIXIN/MOESIN PROTEINS; TYROSINE PHOSPHORYLATION; EPITHELIAL INTEGRITY; FUNCTIONAL-ANALYSIS; ADHERENS JUNCTIONS; STRUCTURAL BASIS; PLASMA-MEMBRANE;

D O I：

10.4161/cam.5.2.15081

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The highly related ERM (Ezrin, Radixin, Moesin) proteins provide a regulated linkage between the membrane and the underlying actin cytoskeleton. They also provide a platform for the transmission of signals in responses to extracellular cues. Studies in different model organisms and in cultured cells have highlighted the importance of ERM proteins in the generation and maintenance of specific domains of the plasma membrane. A central question is how do ERM proteins coordinate actin filament organization and membrane protein transport/stability with signal transduction pathways to build up complex structures? Through their interaction with numerous partners including membrane proteins, actin cytoskeleton and signaling molecules, ERM proteins have the ability to organize multiprotein complexes in specific cellular compartments. Likewise, ERM proteins participate in diverse functions including cell morphogenesis, endocytosis/ exocytosis, adhesion and migration. This review focuses on aspects still poorly understood related to the function of ERM proteins in epithelial cell adhesion and migration.

引用

页码：199 / 206

页数：8

共 78 条

[41] Rho- and Rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: An essential role for ezrin/radixin/moesin proteins [J].