Palladium-catalyzed cross-coupling reactions between dihydropyranylindium reagents and aryl halides.: Synthesis of C-aryl glycals

被引：78

作者：

Lehmann, U ^{[1
]}

Awasthi, S ^{[1
]}

Minehan, T ^{[1
]}

机构：

[1] Harvey Mudd Coll, Dept Chem, Claremont, CA 91711 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 14期

关键词：

D O I：

10.1021/ol0345428

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

graphic Palladium(0)-catalyzed cross-coupling reactions between tris(dihydropyranyl)indium 1 and aryl halides 2 have been investigated. Aryl iodides and electron-deficient aryl bromides couple efficiently with the in situ-generated indium reagents in the presence of 1-5 mol % Cl2Pd(PPh3)(2) to produce substituted dihydropyrans 3 with minimal (<10%) dimer (4) formation. Organoindium reagents derived from D-glucal also undergo cross couplings with aryl iodides to produce C-aryl glycals.

引用

页码：2405 / 2408

页数：4

共 32 条

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[2]

[Anonymous], 1996, PALLADIUM REAGENTS C

[3]

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