Acute behavioral effects of MK-801 in the mouse

被引:42
作者
BrosnanWatters, G [1 ]
Wozniak, DF [1 ]
Nardi, A [1 ]
Olney, JW [1 ]
机构
[1] WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,ST LOUIS,MO 63110
关键词
MK-801; dizocilipine; spatial learning and memory; mice; activity; sensorimotor; NMDA receptor antagonist;
D O I
10.1016/0091-3057(95)02073-X
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The acute effects of 0.05 mg/kg MK-801 on spatial learning and memory in male mice were studied using a modified hole board food search task. Dose-response sensorimotor and activity tests suggested that this dose of MK-801 did not induce significant nonassociative effects. Mice were trained on the hole board using a massed trials protocol to learn the location of a hole baited with a food reward among four corner holes. Retention was tested 24 h later. Mice were split into two groups matched according to acquisition scores. The following week, mice injected with 0.05 mg/kg MK-801 30 min before being trained to a different baited hole were significantly impaired in acquiring a new baited hole location compared to saline-treated mice, although retention performance was unaffected. The same result was found in another experiment in which treatments were crossed over, and a different version of the task was used. However, in another experiment, 0.05 mg/kg MK-801 did not impair performance when the hole board task was well learned.
引用
收藏
页码:701 / 711
页数:11
相关论文
共 41 条
[1]   EFFECTS OF INTRAVENTRICULAR INFUSION OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST AP5 ON SPATIAL MEMORY OF RATS IN A RADIAL ARM MAZE [J].
BOLHUIS, JJ ;
REID, IC .
BEHAVIOURAL BRAIN RESEARCH, 1992, 47 (02) :151-157
[2]  
Brosnan-Watters G., 1994, Society for Neuroscience Abstracts, V20, P1217
[3]  
Brosnan-Watters G., 1993, Society for Neuroscience Abstracts, V19, P1134
[5]   SPATIAL MEMORY AND N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS APV AND MK-801 - MEMORY IMPAIRMENTS DEPEND ON FAMILIARITY WITH THE ENVIRONMENT, DRUG DOSE, AND TRAINING DURATION [J].
CARAMANOS, Z ;
SHAPIRO, ML .
BEHAVIORAL NEUROSCIENCE, 1994, 108 (01) :30-43
[6]   EXCITATORY AMINO-ACIDS IN SYNAPTIC TRANSMISSION IN THE SCHAFFER COLLATERAL COMMISSURAL PATHWAY OF THE RAT HIPPOCAMPUS [J].
COLLINGRIDGE, GL ;
KEHL, SJ ;
MCLENNAN, H .
JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :33-46
[7]   MEASUREMENT OF AN EXPLOSIVE BEHAVIOR IN THE MOUSE, INDUCED BY MK-801, A PCP ANALOG [J].
DEUTSCH, SI ;
HITRI, A .
CLINICAL NEUROPHARMACOLOGY, 1993, 16 (03) :251-257
[8]   DIFFERENT CAPABILITY OF N-METHYL-D-ASPARTATE ANTAGONISTS TO AFFECT LOCOMOTOR/EXPLORATORY ACTIVITY OF MICE IN A COMPUTERIZED ONLINE OPEN-FIELD TEST [J].
DIANA, G ;
SAGRATELLA, S .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1994, 48 (01) :291-295
[9]  
Finch D. M., 1993, NEUROBIOLOGY CINGULA, P224
[10]   NEURONAL VACUOLIZATION AND NECROSIS INDUCED BY THE NONCOMPETITIVE N-METHYL-D-ASPARTATE (NMDA) ANTAGONIST MK(+)801 (DIZOCILPINE MALEATE) - A LIGHT AND ELECTRON-MICROSCOPIC EVALUATION OF THE RAT RETROSPLENIAL CORTEX [J].
FIX, AS ;
HORN, JW ;
WIGHTMAN, KA ;
JOHNSON, CA ;
LONG, GG ;
STORTS, RW ;
FARBER, N ;
WOZNIAK, DF ;
OLNEY, JW .
EXPERIMENTAL NEUROLOGY, 1993, 123 (02) :204-215