The role of proteomics in depression research

被引：65

作者：

Martins-de-Souza, Daniel ^{[1
]}

Harris, Laura W. ^{[2
]}

Guest, Paul C. ^{[2
]}

Turck, Christoph W. ^{[1
]}

Bahn, Sabine ^{[2
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

[2] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1QT, England

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2010年 / 260卷 / 06期

关键词：

Major depressive disorder (MDD); Unipolar MDD; Clinical MDD; Proteomics; CHRONIC ANTIDEPRESSANT TREATMENT; ANTERIOR CINGULATE CORTEX; 2-D DIGE ANALYSIS; GENE-EXPRESSION; NEUROTROPHIC FACTOR; BIPOLAR DISORDER; MITOCHONDRIAL DYSFUNCTION; PREFRONTAL CORTEX; RAT HIPPOCAMPUS; PROTEIN-CHANGES;

D O I：

10.1007/s00406-009-0093-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Depression is a severe neuropsychiatric disorder affecting approximately 10% of the world population. Despite this, the molecular mechanisms underlying the disorder are still not understood. Novel technologies such as proteomic-based platforms are beginning to offer new insights into this devastating illness, beyond those provided by the standard targeted methodologies. Here, we will show the potential of proteome analyses as a tool to elucidate the pathophysiological mechanisms of depression as well as the discovery of potential diagnostic, therapeutic and disease course biomarkers.

引用

页码：499 / 506

页数：8

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