Single-dose pharmacokinetics of levofloxacin during continuous veno-venous haemofiltration in critically ill patients

被引：28

作者：

Traunmüller, F

Thalhammer-Scherrer, R

Locker, GJ

Losert, H

Schmid, R

Staudinger, T

Thalhammer, F

机构：

[1] Univ Vienna, Dept Internal Med 1, Div Infect Dis, A-1090 Vienna, Austria

[2] Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria

[3] Univ Vienna, Intens Care Unit, Dept Internal Med 1, A-1090 Vienna, Austria

[4] Univ Vienna, Inst Virol, A-1090 Vienna, Austria

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2001年 / 47卷 / 02期

关键词：

D O I：

10.1093/jac/47.2.229

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The present study was performed to analyse the pharmacokinetics of levofloxacin during continuous veno-venous haemofiltration (CVVH) with a high-flux polyamide membrane. Twelve patients received 500 mg levofloxacin intravenously. The mean levofloxacin concentration peak was 1.9 +/- 1.0 mg/L. The elimination half-life, haemofiltration clearance and total removal were 8.3 +/- 2.6 h, 27.6 +/- 8.4 mg/Lmin and 56 +/- 19%, respectively. Further multiple-dose studies are required to enable dosage recommendations to be made for patients receiving venal replacement therapy with CVVH.

引用

页码：229 / 231

页数：3

共 11 条

[1] Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses [J].