Photostimulation of mitochondria as a treatment for retinal neurodegeneration

被引：22

作者：

Beirne, Kathy ^{[1
,2
]}

Rozanowska, Malgorzata ^{[1
,2
]}

Votruba, Marcela ^{[1
,2
,3
]}

机构：

[1] Cardiff Univ, Sch Optometry & Vis Sci, Cardiff, S Glam, Wales

[2] Cardiff Univ, Cardiff Inst Tissue Engn & Repair, Cardiff, S Glam, Wales

[3] Univ Wales Hosp, Cardiff Eye Unit, Cardiff, S Glam, Wales

来源：

MITOCHONDRION | 2017年 / 36卷

关键词：

Red light; Near infrared light; Retina; Neurodegeneration; Photostimulation; Low-level light therapy; Photobiomodulation; NEAR-INFRARED LIGHT; LEVEL LASER THERAPY; TRAUMATIC BRAIN-INJURY; NITRIC-OXIDE SYNTHASE; DOPAMINERGIC CELL-SURVIVAL; LIPID-PEROXIDATION; REACTIVE OXYGEN; MOUSE MODEL; VISIBLE RADIATION; INDUCED DAMAGE;

D O I：

10.1016/j.mito.2017.05.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Absorption of photon energy by neuronal mitochondria leads to numerous downstream neuroprotective effects. Red and near infrared (NIR) light are associated with significantly less safety concerns than light of shorter wavelengths and they are therefore, the optimal choice for irradiating the retina. Potent neuroprotective effects have been demonstrated in various models of retinal damage, by red/NIR light, with limited data from human studies showing its ability to improve visual function. Improved neuronal mitochondrial function, increased blood flow to neural tissue, upregulation of cell survival mediators and restoration of normal microglial function have all been proposed as potential underlying mechanisms of red/NIR light.

引用

页码：85 / 95

页数：11

共 101 条

[1]

670 nm light mitigates oxygen-induced degeneration in C57BL/6J mouse retina [J].