Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols

被引：275

作者：

Brown, GC ^{[1
]}

Borutaite, V ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2004年 / 1658卷 / 1-2期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

nitric oxide; mitochondria; complex I; NADH-ubiquinone oxidoreductase; Parkinson's disease; respiration;

D O I：

10.1016/j.bbabio.2004.03.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NO or its derivatives (reactive nitrogen species, RNS) inhibit mitochondrial complex I by several different mechanisms that are not well characterised. There is an inactivation by NO, peroxynitrite and S-nitrosothiols that is reversible by light or reduced thiols, and therefore may be due to S-nitrosation or Fe-nitrosylation of the complex. There is also an irreversible inhibition by peroxynitrite, other oxidants and high levels of NO, which may be due to tyrosine nitration, oxidation of residues or damage of iron sulfur centres. Inactivation of complex I by NO or RNS is seen in cells or tissues expressing iNOS, and may be relevant to inflammatory pathologies, such as septic shock and Parkinson's disease. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：44 / 49

页数：6

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