Resident cardiac mast cells: Are they the major culprit in the pathogenesis of cardiac hypertrophy?

被引：34

作者：

Balakumar, Pitchai ^{[1
]}

Singh, Amrit Pal ^{[2
]}

Ganti, Subrahmanya S. ^{[1
]}

Krishan, Pawan ^{[2
]}

Ramasamy, Subbiah ^{[3
]}

Singh, Manjeet ^{[1
]}

机构：

[1] ISF Inst Pharmaceut Sci & Drug Res, Moga, Punjab, India

[2] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala, Punjab, India

[3] Madurai Kamaraj Univ, Sch Biol Sci, Dept Biochem, Madurai 625021, Tamil Nadu, India

来源：

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | 2008年 / 102卷 / 01期

关键词：

D O I：

10.1111/j.1742-7843.2007.00147.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mast cells originate from pluripotent progenitor cells in bone marrow and are major players in the inflammation process. The involvements of mast cells in various cardiovascular complications such as arrhythmias, ischaemia reperfusion injury and graft rejection are well documented. Moreover, recent studies suggest the involvement of mast cells in cardiac hypertrophy and heart failure. The present review focuses on the role of mast cells in the development of cardiac hypertrophy and heart failure.

引用

页码：5 / 9

页数：5

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