Anti-tumour necrosis factor-α therapy in heart failure:: Future directions

被引：54

作者：

Balakumar, Pitchai ^{[1
]}

Singh, Manjeet ^{[1
]}

机构：

[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India

来源：

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | 2006年 / 99卷 / 06期

关键词：

D O I：

10.1111/j.1742-7843.2006.pto_508.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The elevated level of tumour necrosis factor-alpha (TNF-alpha) in patients with heart failure has triggered interest in investigating the role of TNF-alpha in the pathogenesis of heart failure. Both clinical and experimental evidence has suggested that high levels of TNF-alpha occur in heart failure and lead to progression of left ventricular dysfunction. In addition, it has been documented that inhibition of TNF-alpha reverses its deleterious effects in heart failure. A number of clinical trials have been initiated to investigate the effect of anti-TNF-alpha therapy in patients with heart failure. The discouraging results of recent clinical trials of anti-TNF-alpha therapy in patients with heart failure have raised a number of questions about the role of TNF-alpha in heart failure. The present review critically analyzes the reasons of failure of anti-TNF-alpha therapy in heart failure. Moreover the potential approaches for the development of new anti-TNF-alpha therapy has been discussed which may open new vista of the management of heart failure.

引用

页码：391 / 397

页数：7

共 83 条

[1] PHOSPHATIDIC-ACID SIGNALING MEDIATES LUNG CYTOKINE EXPRESSION AND LUNG INFLAMMATORY INJURY AFTER HEMORRHAGE IN MICE
ABRAHAM, E
BURSTEN, S
SHENKAR, R
ALLBEE, J
TUDER, R
WOODSON, P
GUIDOT, DM
RICE, G
SINGER, JW
REPINE, JE
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (02) : 569 - 575
[2] Inflammatory mediators in chronic heart failure: An overview
Anker, SD
von Haehling, S
[J]. HEART, 2004, 90 (04) : 464 - 470
[3] How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH
Anker, SD
Coats, AJS
[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2002, 86 (2-3) : 123 - 130
[4] Bergman MR, 1996, J PHARMACOL EXP THER, V279, P247
[5] Role of cytokines in heart failure
Blum, A
Miller, H
[J]. AMERICAN HEART JOURNAL, 1998, 135 (02) : 181 - 186
[6] Tumour necrosis factor in chronic heart failure - A peripheral view on pathogenesis, clinical manifestations and therapeutic implications
Bolger, AP
Anker, SD
[J]. DRUGS, 2000, 60 (06) : 1245 - 1257
[7] Results of targeted anti-tumor necrosis factor therapy with etanercept (ENBREL) in patients with advanced heart failure
Bozkurt, B
Torre-Amione, G
Warren, MS
Whitmore, J
Soran, OZ
Feldman, AM
Mann, DL
[J]. CIRCULATION, 2001, 103 (08) : 1044 - 1047
[8] Bozkurt B, 2000, ANN RHEUM DIS, V59, P90
[9] Bozkurt B, 1996, HEART FAIL REV, V1, P211
[10] Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α
Bryant, D
Becker, L
Richardson, J
Shelton, J
Franco, F
Peshock, R
Thompson, M
Giroir, B
[J]. CIRCULATION, 1998, 97 (14) : 1375 - 1381

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