Negative regulators of angiogenesis in inflammatory bowel disease: Thrombospondin in the spotlight

被引：11

作者：

Danese, Silvio ^{[1
]}

机构：

[1] IRCCS Gastroenterol, Ist Clin Humanitas, Div Gastroenterol, IT-20089 Rozzano, Italy

来源：

PATHOBIOLOGY | 2008年 / 75卷 / 01期

关键词：

Crohn's disease; endothelium; inflammatory bowel disease; ulcerative colitis;

D O I：

10.1159/000113791

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Angiogenesis is the growth of new blood vessels. In the two major forms of inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, robust angiogenesis exists, and its blockade may have therapeutic potential, as shown in animal models of experimental intestinal inflammation. While abundant literature is available on the positive regulators of intestinal pathological angiogenesis, e. g. VEGF, bFGF, IL-8, CD40 and CD40L, almost no data exist on negative regulators. Thrombospondin-1 is a negative regulator of angiogenesis, and it plays a new role in IBD-associated angiogenesis. In addition, recombinant thrombospondin-1 may inhibit pathological angiogenesis and may offer a new therapeutic approach to intestinal inflammation. Copyright (c) 2008 S. Karger AG, Basel

引用

页码：22 / 24

页数：3

共 17 条

[1] Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease [J].

Binion, DG ;

West, GA ;

Ina, K ;

Ziats, NP ;

Emancipator, SN ;

Fiocchi, C .

GASTROENTEROLOGY, 1997, 112 (06) :1895-1907

[2] Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease [J].

Binion, DG ;

West, GA ;

Volk, EE ;

Drazba, JA ;

Ziats, NP ;

Petras, RE ;

Fiocchi, C .

LANCET, 1998, 352 (9142) :1742-1746

[3] Mechanisms of angiogenesis and arteriogenesis [J].

Carmeliet, P .

NATURE MEDICINE, 2000, 6 (04) :389-395

[4] Angiogenesis in health and disease [J].

Carmeliet, P .

NATURE MEDICINE, 2003, 9 (06) :653-660

[5] Differential angiogenic regulation of experimental colitis [J].

Chidlow, John H., Jr. ;

Langston, Will ;

Greer, James J. M. ;

Ostanin, Dmitry ;

Abdelbaqi, Maisoun ;

Houghton, Jeffery ;

Senthilkumar, Annamalai ;

Shukla, Deepti ;

Mazar, Andrew P. ;

Grisham, Matthew B. ;

Kevil, Christopher G. .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 169 (06) :2014-2030

[6] Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro [J].

Collin-Osdoby, P ;

Rothe, L ;

Bekker, S ;

Anderson, F ;

Huang, YF ;

Osdoby, P .

JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (10) :1859-1871

[7]

Crivellato Enrico, 2005, Current Drug Targets - Inflammation and Allergy, V4, P9, DOI 10.2174/1568010053622876

[8] Critical role of the CD40-CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease [J].

Danese, S. ;

Scaldaferri, F. ;

Vetrano, S. ;

Stefanelli, T. ;

Graziani, C. ;

Repici, A. ;

Ricci, R. ;

Straface, G. ;

Sgambato, A. ;

Malesci, A. ;

Fiocchi, C. ;

Rutella, S. .

GUT, 2007, 56 (09) :1248-1256

[9] Adhesion molecules in inflammatory bowel disease: Therapeutic implications for gut inflammation [J].

Danese, S ;

Semeraro, S ;

Marini, M ;

Roberto, I ;

Armuzzi, A ;

Papa, A ;

Gasbarrini, A .

DIGESTIVE AND LIVER DISEASE, 2005, 37 (11) :811-818

[10] Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow [J].

Danese, Silvio .

CURRENT OPINION IN GASTROENTEROLOGY, 2007, 23 (04) :384-389

← 1 2 →