Mechanism-based inhibition of monoamine oxidase by 3-aryl-Δ3-pyrrolines

被引：13

作者：

Williams, CH ^{[1
]}

Lawson, J ^{[1
]}

机构：

[1] Queens Univ Belfast, Ctr Med Biol, Sch Biol & Biochem, Belfast BT9 7BL, Antrim, North Ireland

来源：

BIOCHEMICAL JOURNAL | 1998年 / 336卷

关键词：

D O I：

10.1042/bj3360063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The compound 1-methyl-3-phenyl-Delta(3)-pyrroline and its 4-chlorophenyl analogue appear to act as irreversible inhibitors of monoamine oxidase B (MAO B) in mitochondria of rat liver. The compounds are metabolized by MAO B and concomitantly inhibit the enzyme in what seems to be a two-step process. The metabolic end product of this process is the corresponding pyrrole. This inhibition process is considered in the light of possible intermediates formed during the enzymic oxidation, and comparisons are made with the structurally analogous neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

引用

页码：63 / 67

页数：5

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