1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ANALOGS - INACTIVATION OF MONOAMINE-OXIDASE BY CONFORMATIONALLY RIGID ANALOGS OF N,N-DIMETHYLCINNAMYLAMINE

被引：12

作者：

HIEBERT, CK

SILVERMAN, RB

机构：

[1] NORTHWESTERN UNIV,DEPT CHEM,EVANSTON,IL 60208

[2] NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60208

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 08期

关键词：

D O I：

10.1021/jm00403a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1566 / 1570

页数：5

共 33 条

[1]

ALLIS G, 1943, J BIOL CHEM, V147, P487

[2]

BLASCHKO H, 1952, PHARMACOL REV, V4, P415

[3] NEW METHOD FOR METHYLATION OF AMINES [J].

BORCH, RF ;

HASSID, AI .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (10) :1673-&

[4] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[5] CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].

DAVIS, GC ;

WILLIAMS, AC ;

MARKEY, SP ;

EBERT, MH ;

CAINE, ED ;

REICHERT, CM ;

KOPIN, IJ .

PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254

[6] 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND 1-METHYL-4-PHENYLPYRIDINE (MPP+) CAUSE RAPID ATP DEPLETION IN ISOLATED HEPATOCYTES [J].

DIMONTE, D ;

JEWELL, SA ;

EKSTROM, G ;

SANDY, MS ;

SMITH, MT .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 137 (01) :310-315

[7] COMPARATIVE-STUDIES ON THE MECHANISMS OF PARAQUAT AND 1-METHYL-4-PHENYLPYRIDINE (MPP+) CYTOTOXICITY [J].

DIMONTE, D ;

SANDY, MS ;

EKSTROM, G ;

SMITH, MT .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 137 (01) :303-309

[8] SYNTHESIS AND TOXICITY TOWARD NIGROSTRIATAL DOPAMINE NEURONS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) ANALOGS [J].

FRIES, DS ;

DEVRIES, J ;

HAZELHOFF, B ;

HORN, AS .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (03) :424-427

[9] METABOLISM OF THE NEUROTOXIN IN MPTP BY HUMAN-LIVER MONOAMINE OXIDASE-B [J].

FRITZ, RR ;

ABELL, CW ;

PATEL, NT ;

GESSNER, W ;

BROSSI, A .

FEBS LETTERS, 1985, 186 (02) :224-228

[10] Concerning a phenylbutene [J].

Harries, C ;

de Osa, AS .

BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1903, 36 :2997-3002

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