Cell cycle regulators and their abnormalities in breast cancer

被引:35
作者
Fernández, PL [1 ]
Jares, P [1 ]
Rey, MJ [1 ]
Campo, E [1 ]
Cardesa, A [1 ]
机构
[1] Univ Barcelona, IDIBAPS, Hosp Clin Barcelona,Dept Anat Pathol, Inst Invest Biomed August Pi & Sunyer, E-08036 Barcelona, Spain
来源
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 1998年 / 51卷 / 06期
关键词
cell cycle regulators; breast cancer; cyclins; cyclin dependent kinases; retinoblastoma gene product;
D O I
10.1136/mp.51.6.305
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
One of the main properties of cancer cells is their increased and deregulated proliferative activity. It is now well known that abnormalities in many positive and negative modulators of the cell cycle are frequent in many cancer types, including breast carcinomas. Abnormalities such as defective function of the retinoblastoma gene and cyclin-dependent kinase inhibitors (for example, p16, p21, and p27), as well as upregulation of cyclins, are often seen in breast tumours. These abnormalities are sometimes coincidental, and newly described interplays between them suggest the existence of a complex regulatory web in the cell cycle.
引用
收藏
页码:305 / 309
页数:5
相关论文
共 82 条
[1]  
Altucci L, 1996, ONCOGENE, V12, P2315
[2]   MOLECULAR-CLONING AND CHROMOSOMAL MAPPING OF DNA REARRANGED WITH THE PARATHYROID-HORMONE GENE IN A PARATHYROID ADENOMA [J].
ARNOLD, A ;
KIM, HG ;
GAZ, RD ;
EDDY, RL ;
FUKUSHIMA, Y ;
BYERS, MG ;
SHOWS, TB ;
KRONENBERG, HM .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (06) :2034-2040
[3]   p21(WAF1) immunohistochemical expression in breast carcinoma: Correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival [J].
Barbareschi, M ;
Caffo, O ;
Doglioni, C ;
Fina, P ;
Marchetti, A ;
Buttitta, F ;
Leek, R ;
Morelli, L ;
Leonardi, E ;
Bevilacqua, G ;
DallaPalma, P ;
Harris, AL .
BRITISH JOURNAL OF CANCER, 1996, 74 (02) :208-215
[4]   CYCLIN D1 PROTEIN EXPRESSION AND FUNCTION IN HUMAN BREAST-CANCER [J].
BARTKOVA, J ;
LUKAS, J ;
MULLER, H ;
LUTZHOFT, D ;
STRAUSS, M ;
BARTEK, J .
INTERNATIONAL JOURNAL OF CANCER, 1994, 57 (03) :353-361
[5]   CYCLIN D1 AS A CELLULAR PROTOONCOGENE [J].
BATES, S ;
PETERS, G .
SEMINARS IN CANCER BIOLOGY, 1995, 6 (02) :73-82
[6]  
BORG A, 1992, CANCER RES, V52, P2991
[7]   Absence of p16 gene (CDKN2) deletions in microdissected primary breast carcinoma specimens [J].
Calvano, JE ;
Rush, EB ;
Tan, LK ;
Rosen, PP ;
Borgen, PI ;
VanZee, KJ .
ANNALS OF SURGICAL ONCOLOGY, 1997, 4 (05) :416-420
[8]   Decreased levels of the cell-cycle inhibitor p27(Kip1) protein: Prognostic implications in primary breast cancer [J].
Catzavelos, C ;
Bhatacharya, N ;
Ung, YC ;
Wilson, JA ;
Roncari, L ;
Sandhu, C ;
Shaw, P ;
Yeger, H ;
MoravaProtzner, I ;
Kapusta, L ;
Franssen, E ;
Pritchard, KI ;
Slingerland, JM .
NATURE MEDICINE, 1997, 3 (02) :227-230
[9]  
CHEN XB, 1995, CANCER RES, V55, P4257
[10]   A recombinant adenovirus expressing p27(Kip1) induces cell cycle arrest and lass of cyclin-Cdk activity in human breast cancer cells [J].
Craig, C ;
Wersto, R ;
Kim, M ;
Ohri, E ;
Li, ZW ;
Katayose, D ;
Lee, SJ ;
Trepel, J ;
Cowan, K ;
Seth, P .
ONCOGENE, 1997, 14 (19) :2283-2289