The impact of type 1 and type 2 diabetes mellitus on the oocyte and the preimplantation embryo

被引：50

作者：

Jungheim, Emily S. ^{[1
]}

Moley, Kelle H. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO USA

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2008年 / 26卷 / 02期

关键词：

diabetes; oocyte; embryo; glucose transport; insulin resistance;

D O I：

10.1055/s-2008-1042957

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Whereas the importance of close monitoring and tight glycemic control in diabetic pregnancies cannot be ignored, the growing body of knowledge surrounding the different effects of diabetes mellitus on the earliest stages of reproduction underscores the need for aggressive screening among reproductive-aged women at risk for diabetes and the importance of preconceptual counseling among women with known diabetes. This article reviews the salient pathophysiology of type 1 diabetes and type 2 diabetes in reproduction, specifically within the context of the preovulatory oocyte and the preimplantation embryo. In doing so, this review illustrates the need for novel and safe therapies and interventions tailored to address the specific characteristics of these diseases in the periconceptual. period.

引用

页码：186 / 195

页数：10

共 57 条

[51] Mechanisms of disease - Glucose transporters and insulin action - Implications for insulin resistance and diabetes mellitus [J].

Shepherd, PR ;

Kahn, BB .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) :248-257

[52]

Trounson A., 2003, BIOL PATHOLOGY OOCYT

[53] Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome [J].

Velazquez, EM ;

Mendoza, SG ;

Wang, P ;

Glueck, CJ .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1997, 46 (04) :454-457

[54] Involvement of connexin 43 in meiotic maturation of bovine oocytes [J].

Vozzi, C ;

Formenton, A ;

Chanson, A ;

Senn, A ;

Sahli, R ;

Shaw, P ;

Nicod, P ;

Germond, M ;

Haefliger, JA .

REPRODUCTION, 2001, 122 (04) :619-628

[55] A mouse model for Glut-1 haploinsufficiency [J].

Wang, D ;

Pascual, JM ;

Yang, H ;

Engelstad, K ;

Mao, X ;

Cheng, JF ;

Yoo, J ;

Noebels, JL ;

De Vivo, DC .

HUMAN MOLECULAR GENETICS, 2006, 15 (07) :1169-1179

[56] Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis [J].

Wood, Jennifer R. ;

Dumesic, Daniel A. ;

Abbott, David H. ;

Strauss, Jerome F., III .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (02) :705-713

[57] Fetal and neonatal outcomes of diabetic pregnancies [J].

Yang, Joanne ;

Cummings, Elizabeth A. ;

O'Connell, Colleen ;

Jangaard, Krista .

OBSTETRICS AND GYNECOLOGY, 2006, 108 (03) :644-650

← 1 2 3 4 5 6 →