Molecular mechanisms of hemoglobin switching

被引：12

作者：

Jane, SM

Cunningham, JM

机构：

[1] ST JUDE CHILDRENS RES HOSP, WALTER & ELIZA HALL INST MED RES, MEMPHIS, TN 38101 USA

[2] ST JUDE CHILDRENS RES HOSP, DIV EXPT HEMATOL, MEMPHIS, TN 38105 USA

[3] UNIV TENNESSEE, DEPT PEDIAT & BIOCHEM, MEMPHIS, TN 38103 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1996年 / 28卷 / 11期

关键词：

globin genes; transcription; locus control region; developmental regulation; transcription factors;

D O I：

10.1016/S1357-2725(96)00058-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The developmental regulation of the human beta-globin cluster embodies all aspects of transcriptional control of eukaryotic genes. The cis-acting sequences within the cluster, distal regulatory regions and trans-acting factors all contribute to provide stringent temporal and tissue-specific expression. This review will examine the individual regulatory mechanisms which govern globin gene expression and highlight recent advances which expand our understanding of these dynamic interactions. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1197 / 1209

页数：13

共 116 条

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