Apoptosis in disease: about shortage and excess

被引：19

作者：

Brunner, T ^{[1
]}

Mueller, C ^{[1
]}

机构：

[1] Univ Bern, Inst Pathol, Div Immunopathol, CH-3010 Bern, Switzerland

来源：

PROGRAMMED CELL DEATH | 2003年 / 39卷

关键词：

D O I：

10.1042/bse0390119

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The death of cells by apoptosis is a fundamental event in development and the maintenance of cell homoeostasis. The other side of the coin, however, is that excessive cell death by apoptosis or the lack of apoptosis is often the driving force of many diseases. Whereas reduced apoptosis sensitivity is a basic characteristic of many turnout cells, accelerated tissue cell death and loss of tissue functions is the underlying cause of many auto-immune and inflammatory diseases.

引用

页码：119 / 130

页数：12

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