History, challenges and perspectives of cell microencapsulation

被引：267

作者：

Orive, G

Hernández, RM

Gascón, AR

Calafiore, R

Chang, TMS

de Vos, P

Hortelano, G

Hunkeler, D

Lacík, I

Pedraz, JL ^{[1
]}

机构：

[1] Univ Basque Country, Fac Pharm, Lab Pharm & Pharmaceut Technol, Vitoria 01006, Spain

[2] Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy

[3] McGill Univ, Fac Med, Artificial Cells & Organs Res Ctr, Montreal, PQ H3G 1Y6, Canada

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Lab Med, Sect Med Biol, Groningen, Netherlands

[5] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada

[6] AQUA TECH Specialties SA, CH-1283 Geneva, Switzerland

[7] Slovak Acad Sci, Inst Polymer, Dept Special Polymers & Biopolymers, Bratislava 84236, Slovakia

来源：

TRENDS IN BIOTECHNOLOGY | 2004年 / 22卷 / 02期

关键词：

D O I：

10.1016/j.tibtech.2003.11.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is a potentially cost-effective method to treat a wide range of diseases. Although there are several issues that need to be addressed, including capsule manufacture, properties and performance, in the past few years, a stepwise analysis on the essential obstacles and limitations has brought the whole technology closer to a realistic proposal for clinical application. This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way.

引用

页码：87 / 92

页数：6

共 45 条

[1] New microcapsules based on oligoelectrolyte complexation [J].