Acid acclimation by Helicobacter pylori

被引：101

作者：

Sachs, G ^{[1
]}

Weeks, DL

Wen, Y

Marcus, EA

Scott, DR

Melchers, K

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Lab Membrane Biol, Los Angeles, CA 90024 USA

[2] Vet Affairs Greater Los Angeles Hlth Care Syst, Los Angeles, CA USA

[3] Altana Res Inst, Boston, MA USA

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00032.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, Urel, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to similar to 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.

引用

页码：429 / 438

页数：10

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