Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

被引：61

作者：

Grossmann, Vera ^{[1
]}

Kern, Wolfgang ^{[1
]}

Harbich, Stefan ^{[1
]}

Alpermann, Tamara ^{[1
]}

Jeromin, Sabine ^{[1
]}

Schnittger, Susanne ^{[1
]}

Haferlach, Claudia ^{[1
]}

Haferlach, Torsten ^{[1
]}

Kohlmann, Alexander ^{[1
]}

机构：

[1] MLL Munich Leukemia Lab, D-81377 Munich, Germany

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2011年 / 96卷 / 12期

关键词：

T-cell ALL; prognosis; RUNX1; mutations; ACUTE MYELOID-LEUKEMIA; GENE; CLASSIFICATION; MALIGNANCIES; ADULT;

D O I：

10.3324/haematol.2011.043919

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases. In this study, the mutational status of RUNX1 was investigated in 128 acute lymphoblastic leukemia patients. We detected a mutation rate of 18.3% (13 of 71) in patients with T-cell acute lymphoblastic leukemia, 3.8% (2 of 52) in patients with B-cell acute lymphoblastic leukemia and no mutation (0 of 5) in patients with natural killer cell leukemia, respectively. In T-cell acute lymphoblastic leukemia patients, RUNX1 mutations were significantly associated with higher age (P=0.017) and lower white blood cell count (P=0.038). Moreover, an inferior outcome was observed in the subgroup of early T-cell acute lymphoblastic leukemia patients carrying RUNX1 mutations for overall survival (P=0.043). In conclusion, RUNX1 mutations are an important novel biomarker for a comprehensive characterization of T-cell acute lymphoblastic leukemia with poor prognostic impact and have implications for use also in monitoring disease.

引用

页码：1874 / 1877

页数：4

共 23 条

[11] A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases [J].