Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study

被引：187

作者：

Crowe, Francesca L. ^{[1
]}

Roddam, Andrew W. ^{[1
]}

Key, Timothy J. ^{[1
]}

Appleby, Paul N. ^{[1
]}

Overvad, Kim ^{[2
,3
]}

Jakobsen, Marianne U. ^{[4
]}

Tjonneland, Anne ^{[5
]}

Hansen, Louise ^{[5
]}

Boeing, Heiner ^{[6
]}

Weikert, Cornelia ^{[6
]}

Linseisen, Jakob ^{[7
]}

Kaaks, Rudolf ^{[7
]}

Trichopoulou, Antonia ^{[8
]}

Misirli, Gesthimani ^{[8
]}

Lagiou, Pagona ^{[8
]}

Sacerdote, Carlotta ^{[9
]}

Pala, Valeria ^{[10
]}

Palli, Domenico ^{[11
]}

Tumino, Rosario ^{[12
]}

Panico, Salvatore ^{[13
]}

Bueno-de-Mesquita, H. Bas ^{[14
,15
]}

Boer, Jolanda ^{[14
]}

van Gils, Carla H. ^{[16
]}

Beulens, Joline W. J. ^{[16
]}

Barricarte, Aurelio ^{[17
]}

Rodriguez, Laudina ^{[18
]}

Larranaga, Nerea

Sanchez, Maria-Jose ^{[19
]}

Tormo, Maria-Jose ^{[20
]}

Buckland, Genevieve ^{[21
]}

Lund, Eiliv ^{[22
]}

Hedblad, Bo ^{[23
]}

Melander, Olle ^{[24
]}

Jansson, Jan-Hakan ^{[25
]}

Wennberg, Patrik ^{[26
]}

Wareham, Nicholas J. ^{[27
]}

Slimani, Nadia ^{[28
]}

Romieu, Isabelle ^{[28
]}

Jenab, Mazda ^{[28
]}

Danesh, John ^{[29
]}

Gallo, Valentina ^{[30
]}

Norat, Teresa ^{[30
]}

Riboli, Elio ^{[30
]}

机构：

[1] Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Clin Med, Oxford OX3 7LF, England

[2] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[3] Aarhus Univ Hosp, Dept Cardiol, Cardiovasc Res Ctr, Aalborg, Denmark

[4] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[5] Danish Canc Soc, Dept Diet Canc & Hlth, Inst Epidemiol, Copenhagen, Denmark

[6] German Inst Human Nutr, Nuthetal, Germany

[7] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[8] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[9] CPO Piemonte Italy & Human Genet Fdn, Unit Canc Epidemiol, Turin, Italy

[10] Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Nutr Epidemiol Unit, Milan, Italy

[11] ISPO Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[12] Civile MP Arezzo, Canc Registry & Histopathol Unit, Ragusa, Italy

[13] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[14] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[15] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[16] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[17] Publ Hlth Inst Navarra, Pamplona, Spain

[18] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[19] Andalusian Sch Publ Hlth, Granada, Spain

[20] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[21] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[22] Univ Tromso, Inst Community Med, N-9001 Tromso, Norway

[23] Lund Univ, Dept Clin Sci, Skane Univ Hosp, Malmo, Sweden

[24] Lund Univ, Dept Clin Res, Malmo, Sweden

[25] Skelleftea Cty Hosp, Dept Med, Skelleftea, Sweden

[26] Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden

[27] Addenbrookes Hosp, MRC Epidemiol Unit, Cambridge, England

[28] Int Agcy Res Canc IARC WHO, Lyon, France

[29] Univ Cambridge, Cardiovasc Epidemiol Unit, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England

[30] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

来源：

EUROPEAN HEART JOURNAL | 2011年 / 32卷 / 10期

关键词：

Fruits; Vegetables; Coronary disease; Prospective cohort studies; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; RISK; CONSUMPTION; METAANALYSIS; CALIBRATION; HEALTH; CHOLESTEROL; VALIDITY; LIPIDS;

D O I：

10.1093/eurheartj/ehq465

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. Methods and results After an average of 8.4 years of follow-up, there were 1636 deaths from IHD among 313 074 men and women without previous myocardial infarction or stroke from eight European countries. Participants consuming at least eight portions (80 g each) of fruits and vegetables a day had a 22% lower risk of fatal IHD [relative risk (RR) = 0.78, 95% confidence interval (CI): 0.65-0.95] compared with those consuming fewer than three portions a day. After calibration of fruit and vegetable intake to account for differences in dietary assessment between the participating centres, a one portion (80 g) increment in fruit and vegetable intake was associated with a 4% lower risk of fatal IHD (RR = 0.96, 95% CI: 0.92-1.00, P for trend = 0.033). Conclusion Results from this large observational study suggest that a higher intake of fruits and vegetables is associated with a reduced risk of IHD mortality. Whether this association is causal and, if so, the biological mechanism(s) by which fruits and vegetables operate to lower IHD risks remains unclear.

引用

页码：1235 / 1243

页数：9

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