An endoscopic photographic comparison of nasal drug delivery by aqueous spray

被引：29

作者：

Homer, JJ ^{[1
]}

Raine, CH ^{[1
]}

机构：

[1] Bradford Royal Infirm, Dept Otolaryngol, Bradford BD9 6RJ, W Yorkshire, England

来源：

CLINICAL OTOLARYNGOLOGY | 1998年 / 23卷 / 06期

关键词：

nasal cavity; drug administration; intranasal; rhinitis;

D O I：

10.1046/j.1365-2273.1998.2360560.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

There is general agreement that the delivery of topical nasal medication by sprays is suboptimal. This study examines the distribution of spray to the anterior end of the middle turbinate as a guide to the distribution to the middle meatus by means of an endoscopic photographic comparison using dyed aqueous nasal spray. The technique was found to be reproducible. The effect of vigorously inhaling whilst spraying was studied by means of a randomized crossover trial and was found to have no significant effect. This technique could be used in conjunction with other means of assessing intranasal distribution when assessing improved topical nasal drug delivery systems.

引用

页码：560 / 563

页数：4

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