The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance

被引：181

作者：

Farese, Robert V., Jr. ^{[1
,2
]}

Zechner, Rudolf ^{[3
]}

Newgard, Christopher B. ^{[4
,5
]}

Walther, Tobias C. ^{[6
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

[3] Graz Univ, Inst Mol Biosci, Graz, Austria

[4] Duke Univ, Med Ctr, Dept Med, Durham, NC 27704 USA

[5] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27704 USA

[6] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USA

来源：

CELL METABOLISM | 2012年 / 15卷 / 05期

关键词：

FATTY LIVER-DISEASE; MICE; SENSITIVITY; GLUCOSE; OVEREXPRESSION; DIACYLGLYCEROL; DYSLIPIDEMIA; MECHANISMS; OBESITY; STORES;

D O I：

10.1016/j.cmet.2012.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Excessive deposition of fat in the liver (hepatic steatosis) is frequently accompanied by hepatic insulin resistance. Whether this correlation is due to a causal relationship between the conditions has been the subject of considerable debate, and the literature abounds with conflicting data and theories. Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions.

引用

页码：570 / 573

页数：4

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