The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

被引：252

作者：

Ceulemans, An-Gaelle ^{[1
]}

Zgavc, Tine ^{[1
]}

Kooijman, Ron ^{[2
]}

Hachimi-Idrissi, Said ^{[3
,4
]}

Sarre, Sophie ^{[1
]}

Michotte, Yvette ^{[1
]}

机构：

[1] Vrije Univ Brussel, Dept Pharmaceut Chem & Drug Anal, Res Grp Expt Neuropharmacol, B-1090 Brussels, Belgium

[2] Vrije Univ Brussel, Dept Pharmacol, B-1090 Brussels, Belgium

[3] Vrije Univ Brussel, Crit Care Dept, B-1090 Brussels, Belgium

[4] Vrije Univ Brussel, Cerebral Resuscitat Res Grp, B-1090 Brussels, Belgium

来源：

JOURNAL OF NEUROINFLAMMATION | 2010年 / 7卷

关键词：

FOCAL CEREBRAL-ISCHEMIA; TUMOR-NECROSIS-FACTOR; BLOOD-BRAIN-BARRIER; NF-KAPPA-B; INTERCELLULAR-ADHESION MOLECULE-1; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDUCED NEUTROPHIL CHEMOATTRACTANT; CENTRAL-NERVOUS-SYSTEM; POSTISCHEMIC MILD HYPOTHERMIA;

D O I：

10.1186/1742-2094-7-74

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinical settings suggesting that the neuroinflammatory response after an ischemic stroke is not entirely detrimental. This review describes the different key players in neuroinflammation and their possible detrimental and protective effects in stroke. Because of its inhibitory influence on several pathways of the ischemic cascade, hypothermia has been introduced as a promising neuroprotective strategy. This review also discusses the influence of hypothermia on the neuroinflammatory response. We conclude that hypothermia exerts both stimulating and inhibiting effects on different aspects of neuroinflammation and hypothesize that these effects are key to neuroprotection.

引用

页数：18

共 186 条

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