PECAM-1: old friend, new partners

被引：193

作者：

Ilan, N

Madri, JA

机构：

[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

[2] Rappaport Family Inst Res Med Sci, Dept Vasc Biol, Haifa, Israel

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(03)00100-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The maintenance of vascular function is of paramount importance to an organism's existence. PECAM-1 (CD31), first thought of as a marker for endothelia, has been shown to be an important scaffolding molecule involved in several signaling pathways. Recent studies have demonstrated an even wider range of functions for this versatile molecule including participation in maintenance of adherens junction integrity and permeability, organization of the intermediate filament cytoskeleton, regulation of catenin localization and transcriptional activities, participation in STAT isoform signaling, control of apoptotic events, and modulation of cardiac cushion development.

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收藏

页码：515 / 524

页数：10

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