Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells

被引:124
作者
Screpanti, V [1 ]
Wallin, RPA [1 ]
Grandien, A [1 ]
Ljunggren, HG [1 ]
机构
[1] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Dept Med,Ctr Infect Med, S-14186 Huddinge, Sweden
关键词
apoptosis; cytotoxicity; FAS; FASL; NK cells; perforin; tumor;
D O I
10.1016/j.molimm.2004.07.033
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The cytotoxic effector functions of NK cells are important for enabling the immune system to cope efficiently with infection and malignancy. Two major mechanisms of cytotoxicity are perforin/granzyme- and death receptor-mediated (e.g., FASL- or TRAIL-mediated) induction of cell death. Many studies, including studies in perforin-deficient animals, have led to the conclusion that perforin/granzyme-mediated induction of cell death is a principal pathway used by NK cells to eliminate virus-infected or transformed cells. However, death receptor-mediated apoptosis may also contribute to NK cell-mediated cytotoxicity, as revealed by more recent reports. In the present paper, we have reviewed current data on death receptor-mediated tumor cell apoptosis by NK cells with a particular emphasis on the role of NK cell FASL in the RMA/RMA-S tumor model. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:495 / 499
页数:5
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