Clinical review: The antitumoral effects of somatostatin analog therapy in acromegaly

被引：179

作者：

Bevan, JS ^{[1
]}

机构：

[1] Aberdeen Royal Infirm, Dept Endocrinol, Aberdeen AB25 2ZN, Scotland

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2005年 / 90卷 / 03期

关键词：

D O I：

10.1210/jc.2004-1093

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Somatostatin analogs are the mainstay of medical therapy for acromegaly. Suppression of GH hypersecretion, lowering of IGF-I production, and control of symptoms are established benefits of therapy. In addition, clinically significant tumor shrinkage has been seen in a number of studies, particularly in patients undergoing primary medical therapy. This review summarizes current knowledge of the effects of somatostatin analogs on tumor size and cellular morphology and examines the available data on predictors of tumor shrinkage.

引用

页码：1856 / 1863

页数：8

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