Calcium phosphate ceramics as drug-delivery system for anticancer therapy

被引：6

作者：

Landi, E

Orlandi, L

Spagna, G

Tampieri, A

Zaffaroni, N

机构：

[1] CNR, IRTEC, Res Inst Ceram Technol, IT-48016 Faenza, Ravenna, Italy

[2] Natl Inst Study & Treatment Tumors, IT-20133 Milan, Italy

[3] Catania Univ, Fac Pharm, Catania, Italy

来源：

BIOCERAMICS | 2000年 / 192-1卷

关键词：

5-fluorouracil; drug delivery; porous ceramic; release kinetic; beta-TCP;

D O I：

10.4028/www.scientific.net/KEM.192-195.901

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In the present paper the synthesis of P-TCP powder and the design of porous and dense ceramics blocks to be used as drug delivery system were examined. Powder and material preparation methodologies were carefully investigated: 5-fluorouracil (5-FU) was loaded on TCP porous and dense blocks and compacted powders using a vacuum adsorption technique and the addition of various organic fillers to modulate the release kinetic was performed. Our results show that the release can be modulated between 2 and 30 days depending on the different combinations of experimental variables (ceramic microstructure, organic additives, drug load, etc).

引用

页码：901 / 904

页数：4

共 8 条

[1] INFLUENCE OF DEGREE OF CROSS-LINKING ON 5-FLUOROURACIL RELEASE FROM POLY(2-HYDROXYETHYL METHACRYLATE) HYDROGELS [J].