Differences in early lineage segregation between mammals

被引：180

作者：

Kuijk, Ewart W. ^{[1
]}

Du Puy, Leonie ^{[1
,2
]}

Van Tol, Helena T. A.

Oei, Christine H. Y. ^{[1
]}

Haagsman, Henk P. ^{[2
]}

Colenbrander, Ben ^{[1
]}

Roelen, Bernard A. J. ^{[1
]}

机构：

[1] Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, NL-3584 CM Utrecht, Netherlands

[2] Univ Utrecht, Fac Vet Med, Dept Immunol & Infect Dis, Utrecht, Netherlands

来源：

DEVELOPMENTAL DYNAMICS | 2008年 / 237卷 / 04期

关键词：

early lineage segregation; mammals; gene expression patterns;

D O I：

10.1002/dvdy.21480

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

and pluripotent primitive ectoderm. In mouse embryos, Oct4, Cdx2, Nanog, and Gata6 govern these events, but it is unknown whether this is conserved between mammals. Here, the expression patterns of these genes and their products were determined in porcine oocytes and embryos and in bovine embryos. CDX2 and GATA6 expression in porcine and bovine blastocysts resembled that of mouse, indicating conserved functions. However, NANOG expression was undetectable in porcine oocytes and embryos. Some inner cell mass cells in bovine blastocysts expressed NANOG protein. OCT4 protein was undetectable in porcine morulae, but present in both the trophectoderm and the inner cell mass of blastocysts, suggesting that downregulation of OCT4 in the trophectoderm does not precede trophectoderm formation. Combined, the results indicate differences in lineage segregation between mammals.

引用

页码：918 / 927

页数：10

共 45 条

[21] Validation of reference genes for quantitative RT-PCR studies in porcine oocytes and preimplantation embryos [J].

Kuijk, Ewart W. ;

du Puy, Leonie ;

van Tol, Helena T. A. ;

Haagsman, Henk P. ;

Colenbrander, Ben ;

Roelen, Bernard A. J. .

BMC DEVELOPMENTAL BIOLOGY, 2007, 7

[22] Differential gene expression patterns in porcine nuclear transfer embryos reconstructed with fetal fibroblasts and mesenchymal stem cells [J].

Kumar, B. Mohana ;

Jin, Hai-Feng ;

Kim, Jung-Gon ;

Ock, Sun-A ;

Hong, Yonggeun ;

Balasubramanian, S. ;

Choe, Sang-Yong ;

Rho, Gyu-Jin .

DEVELOPMENTAL DYNAMICS, 2007, 236 (02) :435-446

[23] Meiotic and developmental competence of prepubertal and adult swine oocytes [J].

Marchal, R ;

Feugang, JM ;

Perreau, C ;

Venturi, E ;

Terqui, M ;

Mermillod, P .

THERIOGENOLOGY, 2001, 56 (01) :17-29

[24] The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells [J].

Mitsui, K ;

Tokuzawa, Y ;

Itoh, H ;

Segawa, K ;

Murakami, M ;

Takahashi, K ;

Maruyama, M ;

Maeda, M ;

Yamanaka, S .

CELL, 2003, 113 (05) :631-642

[25] GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo [J].

Morrisey, EE ;

Tang, ZH ;

Sigrist, K ;

Lu, MM ;

Jiang, F ;

Ip, HS ;

Parmacek, MS .

GENES & DEVELOPMENT, 1998, 12 (22) :3579-3590

[26] Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 [J].

Nichols, J ;

Zevnik, B ;

Anastassiadis, K ;

Niwa, H ;

Klewe-Nebenius, D ;

Chambers, I ;

Schöler, H ;

Smith, A .

CELL, 1998, 95 (03) :379-391

[27] Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells [J].

Niwa, H ;

Miyazaki, J ;

Smith, AG .

NATURE GENETICS, 2000, 24 (04) :372-376

[28] Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation [J].

Niwa, H ;

Toyooka, T ;

Shimosato, D ;

Strumpf, D ;

Takahashi, K ;

Yagi, R ;

Rossant, J .

CELL, 2005, 123 (05) :917-929

[29] Developmental capacity, energy metabolism and ultrastructure of mature oocytes from prepubertal and adult sheep [J].

OBrien, JK ;

Dwarte, D ;

Ryan, JP ;

Maxwell, WMC ;

Evans, G .

REPRODUCTION FERTILITY AND DEVELOPMENT, 1996, 8 (07) :1029-1037

[30] Generation of germline-competent induced pluripotent stem cells [J].

Okita, Keisuke ;

Ichisaka, Tomoko ;

Yamanaka, Shinya .

NATURE, 2007, 448 (7151) :313-U1

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