Nucleus hears axon's pain

被引:6
作者
Blesch, A [1 ]
Tuszynski, MH
机构
[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
[2] Vet Affairs Med Ctr, La Jolla, CA 92165 USA
关键词
D O I
10.1038/nm0304-236
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Upon injury, axons can send a message to the cell body to implement repair programs. This message is now shown to require a complex of the microtubule motor dynein and proteins that mediates nuclear-cytoplasmic transport.
引用
收藏
页码:236 / 237
页数:2
相关论文
共 13 条
[1]   Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons [J].
Bomze, HM ;
Bulsara, KR ;
Iskandar, BJ ;
Caroni, P ;
Skene, JHP .
NATURE NEUROSCIENCE, 2001, 4 (01) :38-43
[2]   Arginase I and Polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro [J].
Cai, DM ;
Deng, KW ;
Mellado, W ;
Lee, J ;
Ratan, RR ;
Filbin, MT .
NEURON, 2002, 35 (04) :711-719
[3]   Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism [J].
Cai, DM ;
Shen, YJ ;
De Bellard, M ;
Tang, S ;
Filbin, MT .
NEURON, 1999, 22 (01) :89-101
[4]   How does an axon grow? [J].
Goldberg, JL .
GENES & DEVELOPMENT, 2003, 17 (08) :941-958
[5]   Axoplasmic importins enable retrograde injury signaling in lesioned nerve [J].
Hanz, S ;
Perlson, E ;
Willis, D ;
Zheng, JQ ;
Massarwa, R ;
Huerta, JJ ;
Koltzenburg, M ;
Kohler, M ;
van-Minnen, J ;
Twiss, JL ;
Fainzilber, M .
NEURON, 2003, 40 (06) :1095-1104
[6]   Corticospinal neurons up-regulate a range of growth-associated genes following intracortical, but not spinal, axotomy [J].
Mason, MRJ ;
Lieberman, AR ;
Anderson, PN .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (04) :789-802
[7]   Overexpression of GAP-43 in thalamic projection neurons of transgenic mice does not enable them to regenerate axons through peripheral nerve grafts [J].
Mason, MRJ ;
Campbell, G ;
Caroni, P ;
Anderson, PN ;
Lieberman, AR .
EXPERIMENTAL NEUROLOGY, 2000, 165 (01) :143-152
[8]   Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury [J].
Neumann, S ;
Woolf, CJ .
NEURON, 1999, 23 (01) :83-91
[9]   Promoting axonal regeneration in the central nervous system by enhancing the cell body response to axotomy [J].
Plunet, W ;
Kwon, BK ;
Tetzlaff, W .
JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 68 (01) :1-6
[10]   PERIPHERAL INJURY ENHANCES CENTRAL REGENERATION OF PRIMARY SENSORY NEURONS [J].
RICHARDSON, PM ;
ISSA, VMK .
NATURE, 1984, 309 (5971) :791-793