Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor

被引：156

作者：

Garbers, Christoph ^{[1
]}

Thaiss, Wolfgang ^{[2
]}

Jones, Gareth W. ^{[3
]}

Waetzig, Georg H. ^{[4
]}

Lorenzen, Inken ^{[2
]}

Guilhot, Florence ^{[5
]}

Lissilaa, Rami ^{[5
]}

Ferlin, Walter G. ^{[5
]}

Groetzinger, Joachim ^{[2
]}

Jones, Simon A. ^{[3
]}

Rose-John, Stefan ^{[2
]}

Scheller, Juergen ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Biochem & Mol Biol 2, Fac Med, D-40225 Dusseldorf, Germany

[2] Univ Kiel, Inst Biochem, D-24098 Kiel, Germany

[3] Cardiff Univ, Sch Med, Dept Infect Immun & Biochem, Cardiff CF14 4XN, S Glam, Wales

[4] CONARIS Res Inst AG, D-20498 Kiel, Germany

[5] NovImmune SA, CH-1228 Geneva, Switzerland

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 50期

关键词：

IN-VIVO; BIOLOGICAL FUNCTION; DESIGNER CYTOKINE; EPITHELIAL-CELLS; TH17; CELLS; IL-6; INFLAMMATION; RESPONSES; BLOCKADE; CANCER;

D O I：

10.1074/jbc.M111.295758

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Background: IL-6 trans-signaling plays a critical role in chronic inflammation and cancer. Results: The trans-signaling inhibitor sgp130(Fc) also inhibits classic signaling depending on IL-6/sIL-6R ratios. Conclusion: The additional function of sgp130(Fc) suggests that in vivo only low therapeutic concentrations guarantee blockade of trans-signaling but not classic signaling. Significance: The demonstration that the trans-signaling inhibitor can also inhibit classic signaling is central for the field of IL-6 biology.

引用

页码：42959 / 42970

页数：12

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