Pd-catalyzed intramolecular cyclization of pyrrolo-2-carboxamides: regiodivergent routes to pyrrolo-pyrazines and pyrrolo-pyridines

被引：41

作者：

Beccalli, EM

Broggini, G

Martinelli, M

Paladino, G

机构：

[1] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

[2] Univ Milan, Fac Farm, Ist Chim Organ A Marchesini, I-20133 Milan, Italy

[3] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

来源：

TETRAHEDRON | 2005年 / 61卷 / 05期

关键词：

amination; fused-pyrrole system; cyclization reactions; palladium; regioselectivity;

D O I：

10.1016/j.tet.2004.11.066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of N-alkyl-N-allyl-pyrrolo-2-carboxamides with catalytic amounts of palladium derivatives gave regioselectively intramolecular cyclizations to generate bicyclic pyrrolo-fused structures. Pyrrolo[1,2-a]pyrazin-1-ones were achieved in high yields by an amination reaction, while pyrrolo [2,3-c]pyridin-7-ones and pyrrolo[3,2-c]pyridin-4-ones were obtained by an oxidative coupling process. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1077 / 1082

页数：6

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