Massadine, a novel geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa

被引：95

作者：

Nishimura, S

Matsunaga, S

Shibazaki, M

Suzuki, K

Furihata, K

van Soest, RWM

Fusetani, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] Yamanouchi Pharmaceut Co Ltd, Drug Serendip Res Labs, Dept Microbiol Res, Itabashi Ku, Tokyo 1748511, Japan

[3] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan

[4] Univ Amsterdam, Inst Taxon Zool, NL-1009 AT Amsterdam, Netherlands

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 13期

关键词：

D O I：

10.1021/ol034564u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Massadine, a highly oxygenated alkaloid, was isolated from the marine sponge Stylissa aff. massa as an inhibitor of geranylgeranyltransferase type I (GGTase 1). The structure of massadine has been deduced from spectral data. Massidine inhibited GGTase I from Candida albicans with an IC50 value of 3.9 muM.

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页码：2255 / 2257

页数：3

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