Preparation and regiochemical assignments of new pyrazolo[3,4-c][2,1]benzothiazepines

被引：9

作者：

Arranz, E

Diaz, JA

Morante, E

Perez, C

Vega, S

机构：

[1] Inst. de Quim. Médica, CSIC, 28006 Madrid, Juan de la Cierva

[2] Synthelabo, S. A., 28100 Alcobendas (Madrid), Avda

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 01期

关键词：

D O I：

10.1002/jhet.5570330126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of new pyrazolo[3,4-c][2,1]benzothiazepines substituted at the nitrogen atoms of the pyrazole moiety is described. It was carried out by reaction of the 4,9-dihydro-9-methyl-4,10,10-trioxo-1(2)H-pyrazolo [3,4-c] [2,1]benzothiazepine (1) with several alkylating agents under bo th classical and phase-transfer catalysis (PTC) conditions. Assignments of the N-alkyl regioisomers obtained were performed by study of their H-1 nmr spectra and NOE experiments.

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页码：151 / 156

页数：6

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