Survival study of opioid addicts in relation to its adherence to methadone maintenance treatment

被引：59

作者：

Esteban, J

Gimeno, C

Barril, J

Aragonés, A

Climent, JM

Pellín, MD

机构：

[1] Univ Miguel Hernandez, Inst Bioingn, Div Toxicol, E-03202 Elche, Spain

[2] Hosp Gen Univ Alicante, Unidad Conductas Adicticas, Alicante, Spain

[3] Hosp Gen Univ Alicante, Ctr Drogodepencias Cruz Roja, Alicante, Spain

[4] Hosp Gen Univ Alicante, Serv Rehabil, Alicante, Spain

来源：

DRUG AND ALCOHOL DEPENDENCE | 2003年 / 70卷 / 02期

关键词：

methadone; retention; time within treatment; mortality;

D O I：

10.1016/S0376-8716(03)00002-4

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Objectives: To study the putative role of methadone maintenance treatment in the improvement of life expectancy of opioid addicts. Design: Retrospective longitudinal study. Participants: All 1487 patients receiving methadone maintenance treatment in Alicante between June 1990 and December 1997. Statistical analysis: Mortality rates were studied using Kaplan-Meier survival curves. Protection or risk factors were analyzed using Cox's proportional hazards model. Results: Mortality rates decreased from 87/1000 in 1991 to 17/1000 in 1997. The following factors influenced mortality: HIV infection [Hazard Ratio (HR) = 7, 95% confidence interval (CI) = 4-12]; current methadone status (HR = 3.2, 95%CI 1.5-7.1) and MMT retention (retained vs. dropout, HR = 0.5, 95%CI = 0.2-1.1; re-enrolled vs. drop-out, HR = 0.3, 95%CI = 0.2-0.5). Conclusion: Expediting entry and re-enrolling in methadone maintenance treatment improves survival. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：193 / 200

页数：8