Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry

被引：74

作者：

Marder, M

Viola, H

Bacigaluppo, JA

Colombo, MI

Wasowski, C

Wolfman, C

Medina, JH

Rúveda, EA

Paladini, AC

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Inst Quim & Fisicoquim Biol, RA-1113 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencias, RA-1121 Buenos Aires, DF, Argentina

[3] Univ Nacl Rosario, Inst Quim Organ & Sintesis, RA-2000 Rosario, Santa Fe, Argentina

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 249卷 / 02期

关键词：

D O I：

10.1006/bbrc.1998.9146

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Solution phase combinatorial synthesis of flavone derivatives and evaluation of their affinity for the central benzodiazepine receptors is described. The libraries preparation is simple and provides a convenient method for rapid compound generation and screening. Thirty one new compounds were obtained of which the most promising, as high affinity benzodiazepine receptor ligands, were 6-bromo-3'-fluoro-flavone; 6,3'-dichloroflavone; 6-bromo-3'-chloroflavone and 6-chloro-5'-bromoflavone. (C) 1998 Academic Press.

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收藏

页码：481 / 485

页数：5

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