Suppression of aging in mice by the hormone Klotho

被引：1485

作者：

Kurosu, H

Yamamoto, M

Clark, JD

Pastor, JV

Nandi, A

Gurnani, P

McGuinness, OP

Chikuda, H

Yamaguchi, M

Kawaguchi, H

Shimomura, I

Takayama, Y

Herz, J

Kahn, CR

Rosenblatt, KP

Kuro-o, M

机构：

[1] Univ Texas, SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA

[3] Vanderbilt Univ, Sch Med, Dept Physiol & Mol Biophys, Nashville, TN 37232 USA

[4] Univ Tokyo, Dept Sensory & Motor Syst Med, Bunkyo Ku, Tokyo 1138655, Japan

[5] Osaka Univ, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

[6] Harvard Univ, Sch Med, Joslin Diabet Ctr, Dept Med,Res Div, Boston, MA 02215 USA

来源：

SCIENCE | 2005年 / 309卷 / 5742期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1126/science.1112766

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.

引用

页码：1829 / 1833

页数：5

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