Integration of reaction and separation in manufacturing of pharmaceuticals: Membrane-mediated production of S-Ibuprofen

被引：21

作者：

Cauwenberg, V ^{[1
]}

Vergossen, P ^{[1
]}

Stankiewicz, A ^{[1
]}

Kierkels, H ^{[1
]}

机构：

[1] DSM Res, NL-6160 MD Geleen, Netherlands

来源：

CHEMICAL ENGINEERING SCIENCE | 1999年 / 54卷 / 10期

关键词：

membrane reactor; product inhibition; optically active S-ibuprofen; two-phase system;

D O I：

10.1016/S0009-2509(99)00079-2

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The integration of the reaction and separation in a multifunctional reactor unit for the enantioselective production of S-ibuprofen is studied, both experimentally and by kinetic modeling. The ultrafiltration by a commercially available polyacrylonitril membrane is used for the in-situ removal of the product. The application of the on-line ultrafiltration leads to a twofold increase in the overall productivity, that is due to the decrease of the deactivation and inhibition of the enzyme caused by the product. After initial decrease, probably caused by the fouling the fluxes through the membrane remain stable for a long period of time. The concept presents a promising option for other systems with conversion limited by the inhibitory effect of the products. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1473 / 1477

页数：5