Enantioselective organocatalyzed a sulfenylation of aldehydes

被引：830

作者：

Marigo, M ^{[1
]}

Wabnitz, TC ^{[1
]}

Fielenbach, D ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Danish Natl Res Fdn, Ctr Catalysis, DK-8000 Aarhus C, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 05期

关键词：

aldehydes; asymmetric catalysis; enantioselectivity; organocatalysis; sulfenylation;

D O I：

10.1002/anie.200462101

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The facile elaboration of optically active α-sulfanyl-substituted aldehydes makes their direct preparation from unmodified aldehydes and 1-benzylsulfanyl-1,2,4-triazole particularly valuable. The substituted aldehydes are formed with excellent enantioselectivities in the presence of sterically demanding chiral pyrrolidine derivatives as organocatalysts (see scheme). R, R′ = H, alkyl, allyl, benzyl, Ph.

引用

页码：794 / 797

页数：4

共 44 条

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