The safety and immunogenicity of a CETP vaccine in healthy adults

被引：102

作者：

Davidson, MH

Maki, K

Umporowicz, D

Wheeler, A

Rittershaus, C

Ryan, U

机构：

[1] Chicago Ctr Clin Res, Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60610 USA

[2] AVANT Immunotherapeut Inc, Needham, MA USA

来源：

ATHEROSCLEROSIS | 2003年 / 169卷 / 01期

关键词：

cholesterol ester transfer protein (CETP); vaccine; auto-antibodies;

D O I：

10.1016/S0021-9150(03)00137-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A cholesterol ester transfer protein (CETP) vaccine (CETi-1) that induces auto-antibodies that specifically bind and inhibit activity of endogenous CETP has been demonstrated in rabbits to significantly increase HDL-C and reduce the development of atherosclerosis. In a Phase I human trial with CETi-1, one patient at the highest dose (250 mg) out of a total of 36 patients who received a single injection developed anti-CETP antibodies. In an extension study of 23 patients, 53%, (8/15) who received a second injection of the active vaccine developed anti-CETP antibodies compared with 0% (0/8) in the placebo group. The vaccine was well tolerated and no significant laboratory abnormalities occurred. CETi-1 is a feasible therapy in humans to induce CETP autoantibodies. Future research will determine if repeat inoculations will induce a sufficient anti-CETP antibody response to inhibit CETP and increase HDL levels. (C) 2003 Published by Elsevier Science Ireland Ltd.

引用

页码：113 / 120

页数：8

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