Use of X-ray co-crystal structures and molecular modeling to design potent and selective non-peptide inhibitors of cathepsin K

被引：39

作者：

DesJarlais, RL

Yamashita, DS

Oh, HJ

Uzinskas, IN

Erhard, KF

Allen, AC

Haltiwanger, RC

Zhao, BG

Smith, WW

Abdel-Meguid, SS

D'Alessio, K

Janson, CA

McQueney, MS

Tomaszek, TA

Levy, MA

Veber, DF

机构：

[1] SmithKline Beecham Pharmaceut, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA

[2] SmithKline Beecham Pharmaceut, Dept Med Chem, King Of Prussia, PA 19406 USA

[3] SmithKline Beecham Pharmaceut, Dept Analyt Chem, King Of Prussia, PA 19406 USA

[4] SmithKline Beecham Pharmaceut, Dept Biol Struct, King Of Prussia, PA 19406 USA

[5] SmithKline Beecham Pharmaceut, Dept Prot Biochem, King Of Prussia, PA 19406 USA

[6] SmithKline Beecham Pharmaceut, Dept Mol Recognit, King Of Prussia, PA 19406 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 35期

关键词：

D O I：

10.1021/ja981171v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：9114 / 9115

页数：2

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