GENOME:: a rapid coalescent-based whole genome simulator

被引：96

作者：

Liang, Liming ^{[1
]}

Zollner, Sebastian ^{[1
]}

Abecasis, Goncalo R. ^{[1
]}

机构：

[1] Univ Michigan, Ctr Stat Genet, Dept Biostat, Ann Arbor, MI 48109 USA

来源：

BIOINFORMATICS | 2007年 / 23卷 / 12期

关键词：

D O I：

10.1093/bioinformatics/btm138

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

GENOME proposes a rapid coalescent-based approach to simulate whole genome data. In addition to features of standard coalescent simulators, the program allows for recombination rates to vary along the genome and for flexible population histories. Within small regions, we have evaluated samples simulated by GENOME to verify that GENOME provides the expected LD patterns and frequency spectra. The program can be used to study the sampling properties of any statistic for a whole genome study.

引用

页码：1565 / 1567

页数：3

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