A simple and clean procedure for three-component synthesis of spirooxindoles in aqueous medium

被引：266

作者：

Zhu, Song-Lei ^{[1
,2
]}

Ji, Shun-Jun ^{[1
]}

Zhang, Yong ^{[1
]}

机构：

[1] Suzhou Univ, Coll Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Xuzhou Med Coll, Dept Chem, Xuzhou 221002, Peoples R China

来源：

TETRAHEDRON | 2007年 / 63卷 / 38期

基金：

中国国家自然科学基金;

关键词：

spirooxindole; aqueous medium; three-component synthesis;

D O I：

10.1016/j.tet.2007.06.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient one-pot three-component synthesis of the biologically important spirooxindoles scaffold was carried out by the reaction of isatin, activated methylene reagent, and 1,3-dicarbonyl compounds in aqueous medium. This method is of great value because of its environmentally benign character, high yield processing, and easy handling. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：9365 / 9372

页数：8

共 35 条

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