Conversion of Staphylococcus epidermidis strains from commensal to invasive by expression of the ica locus encoding production of biofilm exopolysaccharide

被引：71

作者：

Li, HL

Xu, L

Wang, JP

Wen, YM

Voung, C

Otto, M

Gao, Q

机构：

[1] Fudan Univ, Shanghai Med Coll, Key Lab Med Mol Virol, Shanghai 200032, Peoples R China

[2] NIAID, Rocky Mt Lab, Lab Human Bacterial Pathogenesis, NIH, Hamilton, MT 59840 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 05期

关键词：

D O I：

10.1128/IAI.73.5.3188-3191.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To test if biofilm formation in Staphylococcus epidermidis is dependent on the polysaccharide intercellular adhesin, whose biosynthesis is driven by the ica locus, a plasmid containing the ica locus was transferred to three ica-negative strains. Using in vitro biofilm assays and a rat central venous catheter infection model, we confirmed the importance of the ica locus for biofilm production and pathogenesis of S. epidermidis.

引用

收藏

页码：3188 / 3191

页数：4

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